Endometrium

DUB (Benign Endometrial Fragments and stromal breakdown cw Anovulatory Cycles...BEFAC)

  1. Polyp
  2. Anovulation (Persistent Follicle):
  3. Endometritis
  4. Submucosal leiomyoma

Evaluating Stromal Breakdown

PAMRAG - Pseudomycotic radiate granules

FISE - Fragments of inactive superficial endometrium (age >50)

Hyperplasia DDx

  1. EIN
  2. Polyp
  3. Estrogen

Squamous Morules DDx
(Metaplasia not equal to Benign, "Altered Differentiation State")

  1. APA
  2. Adenoca
  3. EIN
  4. SCC

EIN Criteria

  1. Glands > stroma
  2. Cytology differs in architecturally crowded focus vs endometrium background
  3. Size > 1 mm
  4. Exclude Carcinoma if
  5. p53 positive, PTEN loss

Cervix vs Endometrium

Stain Cervix Endometrium
ER/PR 0 +
VN 0 +
p16 + 0

Endometrial mucinous metaplasia = alternating pink and blue